Концепция «болезни барьерного органа» в патогенезе спондилоартритов
https://doi.org/10.14412/1995-4484-2016-199-205
Аннотация
В настоящее время созданы предпосылки для изменения научного взгляда на этиологию и патогенез спондилоартритов (СпА). Важная роль отводится нарушению функционирования и целостности так называемых барьерных органов, выстраивающих защиту человека между его внутренней и внешней средой. Современные данные о клеточно-молекулярных механизмах патогенеза СпА позволяют ревматологам выдвинуть гипотезу о концепции «болезни барьерного органа» как доклинической стадии развития заболеваний, входящих в группу СпА. Существуют основания предполагать, что в этом процессе задействованы индивидуальные генетические и иммунные факторы, приводящие к повреждению поверхностного эпителия слизистых оболочек и эпидермиса, который служит первым защитным барьером врожденного иммунитета и находится в контакте с чрезвычайно большим количеством микроорганизмов (микробиомом) и с патоген-ассоциированными молекулярными структурами. Микробиом может оказывать влияние на доклиническую фазу болезни несколькими способами, в том числе путем изменений состава микрофлоры (дисбиоз), а также действуя в качестве мишеней иммунологической дисрегуляции.
Ключевые слова
Об авторах
Е. А. ГалушкоРоссия
учебно-методический отдел с центром информационных технологий
заведующая отделом, докт. мед. наук
А. В. Гордеев
Россия
лаборатория микроциркуляции и воспаления
ведущий научный сотрудник лаборатории, докт. мед. наук
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Рецензия
Для цитирования:
Галушко Е.А., Гордеев А.В. Концепция «болезни барьерного органа» в патогенезе спондилоартритов. Научно-практическая ревматология. 2016;54(2):199-205. https://doi.org/10.14412/1995-4484-2016-199-205
For citation:
Galushko E.A., Gordeev A.V. THE CONCEPT OF BARRIER ORGAN DISEASE IN THE PATHOGENESIS OF SPONDYLOARTHRITIS. Rheumatology Science and Practice. 2016;54(2):199-205. (In Russ.) https://doi.org/10.14412/1995-4484-2016-199-205